Nanyang Technological University

Yisheng Biopharma (singapore) Pte Ltd

Xu Ming Zhang

Yi Zhang

Ai Qun Liu

Yuhe Yan

Thomas Anthony Coton

Xiao Jun Liang

Yi Sun

A method for adapting an influenza virus to Vero cells is provided. The method comprises infecting Vero cells with the influenza virus, cultivating the infected Vero cells, harvesting influenza viruses of each passage, wherein infectious dose of the influenza viruses of one passage is greater than or equal to infectious dose of the influenza viruses of a previous passage. The present disclosure also relates to a composition. Said composition comprises polyriboinosinic acid-polyribocytidylic acid, at least one antibiotic or polyamide compound, at least one positive ion, influenza viruses and/or influenza antigens, wherein said influenza viruses and/or influenza antigens are acquired from Vero cell adapted influenza viruses.

Method for adapting influenza viruses to Vero cells

An apparatus and method for analyzing biological cells and other particles using an external laser cavity. Microfluidic channels contain and transport biological cells to be analyzed. A laser diode provides light for cell analysis. An external cavity is provided between one surface of the laser diode and a mirror opposite thereto. A microlens set focuses the light on only one cell as it passes through the external cavity. The presence of the cell in the external cavity gives a weak feedback toward the laser diode. The emission frequency and the output power of the laser are both functions of the length of the external cavity. Therefore, the variation of cavity length can be deduced from these parameters, where the variation is caused by changing the refractive index or size of the cell in the cavity.

Cell analysis using laser with external cavity

Growing community of inventors

Singapore, Singapore

Xu Ming Zhang