Meishan Crrc Fastening System Co., Ltd

Bioage Labs, Inc.

Hitgen, Inc.

Xu He

Yu Liu

Yunlong Jia

Xiangyun Zhao

Guangcheng Dai

Kai Fu

George D Hartman

Yang Liu

Wei Li

Paul Humphries

Kevin Edward Leif Wilhelmsen

Long Guo

Tao Deng

Xia Wang

Shuping Pan

Shibo Wang

Xiong Zhang

Chuanqi Li

Jia Du

Lifang Zhang

Xinrong Li

Yong Wan

Fangnian Hu

Guanglian Xiong

The present disclosure relates to compounds of Formula I: that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.

Inhibitors of NLRP3 inflammasome

A single groove single-sided fastener comprises: a rivet consisting of a rivet head, a polish rod, a locking groove, a tail pulling groove and a tail tooth in sequence, and a lantern ring consisting of a sleeve and a dead head; a tail of the rivet is of a single groove short-tail structure, a ratio of a length of the tail pulling groove to a total length of the tail tooth is 0.1&#x2dc;1.5, an included angle between a bottom generatrix of the tail pulling groove and an axis of the rivet is &#x2212;30&#xb0;&#x2dc;0&#xb0;, two axial ends of the bottom of the tail pulling groove and the tail of the tail tooth are of a fillet transition structure, a ratio of a length of a straight part of the tail tooth to the total length of the tail tooth is 0.1&#x2dc;1.

Single groove single-sided fastener and installation method thereof

Provided is a single-groove and short-tail pulling rivet and an erection method thereof, and the pulling rivet comprises a single groove and a short tail having a broached groove with a continuous and smooth cambered surface, and is characterized by easy manufacturing, low cost and convenient erection. The broached groove is an arc surface with three sections of different radiuses, which solves stress concentration and sticking of a single-groove and short-tail rivet during riveting, and allows a claw of a riveting machine to be engaged to the best position automatically. The tooth profile of a locking groove section of the rivet is a curve combining an arc and a straight line, which greatly improves fastening force. In a word, the invention solves insufficient clamping degree of the short tail, seizing during riveting, blocking of the broached groove, failed riveting, shortage and loss of tightness of existing short-tail pulling rivets, and meets the performance and reliability requirements of the fastening systems for rolling stocks.

Single-groove and short-tail pulling rivet and erection method thereof

The invention discloses a detachable double-locking riveting dismounting method and a pulling rivet. A lantern ring comprises a thin-wall hook section, a thick-wall locking section and a lantern ring head with an annular step from front to back. The rivet comprises a rivet head of an annular groove matched with the hook section, a front polish rod section, a knurling section matched with the locking section, a separating groove, a rear polish rod and a tail annular groove section from front to back. Double riveting is used by inserting the rivet and lantern ring from both sides; after riveting, the locking section and knurling section form radial locking, and the hook section is buckled to form axial locking. Simple detaching tools (e.g. front snap ring and center cylinder) are equipped to dismount rivets rapidly.

Detachable double-locking riveting dismounting method and pulling rivet

Growing community of inventors

Sichuan, China

Xu He