Zhejiang Jingxin Pharmaceutical Co., Ltd.

Xiurong Hu

Jianrong Zhu

Chunyong Peng

Hongban Zhong

Crystal forms I and II of tasimelteon. Crystal form I: an X-ray powder diffraction spectrum using CuK&#x3b1; radiation and represented by a 2&#x3b8; angle has diffraction peaks at least at 7.2&#xb0;&#xb1;0.2&#xb0;, 7.9&#xb0;&#xb1;0.2&#xb0;, 10.6&#xb0;&#xb1;0.2&#xb0;, 14.4&#xb0;&#xb1;0.2&#xb0;, 15.9&#xb0;&#xb1;0.2&#xb0;, 17.3&#xb0;&#xb1;0.2&#xb0;, 21.0&#xb0;&#xb1;0.2&#xb0;, 23.2&#xb0;&#xb1;0.2&#xb0;, and 24.4&#xb0;&#xb1;0.2&#xb0;. Crystal form II: an X-ray powder diffraction spectrum using CuK&#x3b1; radiation and represented by a 2&#x3b8; angle has diffraction peaks at least at 6.8&#xb0;&#xb1;0.2&#xb0;, 12.1&#xb0;&#xb1;0.2&#xb0;, 12.5&#xb0;&#xb1;0.2&#xb0;, 13.1&#xb0;&#xb1;0.2&#xb0;, 13.6&#xb0;&#xb1;0.2&#xb0;, 13.8&#xb0;&#xb1;0.2&#xb0;, 15.8&#xb0;&#xb1;0.2&#xb0;, 17.0&#xb0;&#xb1;0.2&#xb0;, 18.4&#xb0;&#xb1;0.2&#xb0;, 20.8&#xb0;&#xb1;0.2&#xb0;, 24.2&#xb0;&#xb1;0.2&#xb0;, and 24.4&#xb0;&#xb1;0.2&#xb0;. Crystal forms I and II of tasimelteon have advantages of excellent physicochemical property, good stability and solubility, and simple operation for preparation.

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Xinchang County, China

Xiurong Hu