Chinese Academy of Medical Sciences

Jinan University

Shijiazhuang Yiling Pharmaceutical Co., Ltd.

Xiuqi Bao

Dan Zhang

Yang Yu

Yang Lv

Ping Xie

Xinsheng Yao

Shiying Yang

Yang Ni

Gengtao Liu

Caixía Zang

Lin Li

Hao Gao

Yuanpeng Zheng

Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namelyEllis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (HO) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by HOand L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.

Crocins compounds and uses thereof

The present invention discloses a type-G crystal form of fenolamine, a preparation method thereof, and a composition and use thereof. In particular, disclosed is a type-G crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-G fenolamine crystal form in solid state; a method for preparing the solid of type-G crystal form; and use of the solid of the type-G fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD). 

Type-G crystal form of fenolamine, preparation method, composition and use thereof

The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD). 

Type-B fenolamine crystal form, preparation method, composition and use thereof

A composition, and a crocins active site extracted fromEllis, mainly comprising the following ingredients: crocetin di-&#x3b2;-D-gentiobioside, crocetin-&#x3b2;-D-glucopyranosyl-&#x3b2;-D-gentiobioside, crocetin di-&#x3b2;-D-glucopyranoside, 13Z-crocetin di-&#x3b2;-D-gentiobioside, neocrocin B, crocetin mono-&#x3b2;-D-gentiobioside, 13Z-crocetin-8-O-&#x3b2;-D-gentiobioside, 13Z-crocetin-8'-O-&#x3b2;-D-gentiobioside, and crocetin mono-&#x3b2;-D-glucopyranoside. Pharmacological experiment results show that the crocins active site can effectively improve learning and memory injuries in mice induced by scopolamine and amyloid &#x3b2; protein.

Composition, crocins active site, and uses thereof

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Xiuqi Bao