The Scripps Research Institute

University of South Florida

H. Lee Moffitt Cancer Center and Research Institute, Inc.

University of Florida Research Foundation Inc

Modulation Therapeutics

Xiuling Li

Christoph Rader

Mark L McLaughlin

Lori Hazlehurst

Haiyong Peng

The invention provides antibodies, antibody fragments or antigen-binding fragments, as well as related antibody drug conjugates (ADCs) and chimeric antigen receptors (CARs), that specifically recognize human ROR2. Also provided in the invention are methods of using such antibodies in various diagnostic and therapeutic applications.

ROR2 antibody compositions and related methods

The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound adduct, a method for treating disorders such as proliferation disorders (e.g., malignancies), bone deficiency diseases, and autoimmune diseases, and a method for suppressing the growth of, or inducing apoptosis in, cells (e.g., malignant cells).

Cyclic peptide conjugates and methods of use

The disclosure provides antibodies, antibody fragments or antigen-binding fragments, as well as related antibody drug conjugates (ADCs) and chimeric antigen receptors (CARs), that specifically recognize human ROR2, Also provided in the disclosure are methods of using such antibodies in various diagnostic and therapeutic applications.

Growing community of inventors

Jupiter, FL, United States of America

Xiuling Li