Chinese Academy of Sciences

University of California

Xiuli Zhang

Zhiwei Wang

Xinmiao Liang

Chaoran Wang

Olivier Civelli

Yan Zhang

Zhimou Guo

Jixia Wang

Yaopeng Zhao

Changjian Wang

Yanxiong Ke

Yanfang Liu

Nana Du

Lien Wang

The disclosure relates to a 2-(2,2-diarylethyl)-cyclic amine derivative or salt, a synthesis method, an application and a composition thereof. Biological activity test shows that this kind of 2-(2,2-diarylethyl)-cyclic amine derivative has good M-receptor antagonistic activity; and can be used as an active component of drugs for the treatment of the diseases mediated or regulated by muscarinic receptors, such as asthma, chronic obstructive pulmonary disease (COPD), overactive bladder (OAB), bronchospasm with chronic obstructive pulmonary disease, visceral spasm, irritable bowel syndrome, Parkinson's disease, depression or anxiety, schizophrenia and related mental diseases.

2-(2,2-diarylethyl)-cyclic amine derivative or salt, synthesis method, application and composition thereof

A method of treating nervous system diseases associated with dopamine receptors comprising administering a patent in need a compound having a structure of general formula (I) or a pharmaceutical acceptable salt, hydrate, or solvate thereof in a pharmaceutically effective amount, and a method of making the compound having the structure of general formula (I) or a pharmaceutical acceptable salt, hydrate, or solvate thereof. The compound of formula (I) has multiple pharmacological functions such as the functions of activating opioid receptors and blocking dopamine D2 receptors, and has good physicochemical properties and oral bioavailability. General animal experiments show that such a compound has significant and long-lasting analgesic and calming effects and can be used to treat pain and other mental illnesses.

Use and preparation method of berberine compounds

Growing community of inventors

Liaoning, China

Xiuli Zhang