Shaanxi University of Science and Technology

Shaanxi Panlong Pharmaceutical Co., Ltd.

Xixian New District Fenghou Original Pharmaceutical Technology Co., Ltd.

Xiuding Yang

Chengyuan Liang

Jingyi Li

Liang Xin

Lei Tian

Shaojun Zhang

Yuting Liu

Xiaolin Xie

Dezhu Zhang

Xuhua Zhou

Zhao Ma

Kangxiong Wu

Sundian Liu

Han Li

Bin Tian

Qianqian Zhao

Dan Yang

Juan Li

Yongbo Wang

Gennian Mao

Nan Hui

Wenbo Yao

Guaiping Qiao

Jie Zhang

Juan Xia

Ruina Bian

Yuqing Zhao

Yanzi Wang

Kairui Kang

Boyang Li

Chenguan Liang

Changhua Ke

Jiaxuan Li

Ying Zhou

The present invention discloses a pleuromutilin derivative containing thiazole-pyridine benzyl quaternary ammonium salt side chain and a preparation method and use thereof and belongs to the field of medicinal chemistry. A pleuromutilin derivative with thiazole-pyridine benzyl quaternary ammonium salt side chain is successfully prepared by structural reconstruction of pleuromutilin and then structural modification with a quaternary ammonium salt compound. This compound synthesis method has the advantages of easily available raw materials, simple operation and high product yield, and is suitable for industrial production. The results of in vitro pharmacological experiments show that the pleuromutilin derivative of the present invention have good antibacterial and anti-mycoplasma activities, as well as good solubility, and these results show that the pleuromutilin derivative is of great value in the development of an anti-pathogenic microorganism drug.

Pleuromutilin derivative containing thiazole-pyridine benzyl quaternary ammonium salt side chain and preparation method and use thereof

The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLactivity, and is useful in the preparation of a SARS-CoV-2 3CLinhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLinhibitors and anti-SARS-CoV-2 drugs.

3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and preparation method and use thereof

A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I) R, R, R, Rand Rare independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

Pleuromutilin cinnamic acid ester compounds with activities against antibiotic-resistant infections

Disclosed is a compound of formula I, a pharmaceutically acceptable salt, or a tautomer thereof. formula I. R, R, Rand Rare independently selected from the group consisting of hydrogen, methyl group, tert-butyl group, methoxy group, difluoromethyl, trifluoromethyl, trifluoromethoxy, nitro, halogen, phenyl and aromatic heterocyclic; Ris a hydrogen or halogen; and Ris hydrogen, C1-4 alkane or C1-4 cycloalkane.

3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof

A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

Pleuromulin 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ester with antibacterial activity and a method of preparing the same

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Xi'an, China

Xiuding Yang