Merck Sharp + Dohme Corp.

Shanghai Magic Wheels Sporting Goods Co., Ltd.

Xiu Wang

Mark E Layton

Anthony J Roecker

Xuanjia Peng

Melissa S Egbertson

Dansu Li

Deping Wang

Lei Feng

Kristen L G Jones

Disclosed are compounds of Formula A, or a salt thereof: Wherein 'A', R, R, R, R, and Rare as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch and neuropathic pain disorders using the same.

Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels

Disclosed are compounds of Formula A-a, or a salt thereof: Where 'B' and 'R' through &#x201c;R&#x201d; are as defined herein, which compounds have properties for blocking Na1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same. 

Bicycloamine-substituted-N-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels

The invention discloses a wheel structure and a scooter comprising the wheel structure. The wheel structure comprises: an inner rim having a first inner annular face and a first outer annular face that are arranged radially, the first inner annular face is hollow and provided with an interface for connecting to a steering mechanism of the scooter; an outer rim having a second inner annular face which is arranged radially and a second outer annular face for contacting the ground; wherein an intermediate connecting assembly is disposed between the first outer annular face of the inner rim and the second inner annular face of the outer rim, and the outer rim, without need for hub, contacts the inner rim in a rolling manner via the intermediate connecting assembly and is rotatable relative to the inner rim. The wheel structure does not contain a hub and presents a hollow visual effect of the wheel.

Hubless wheel

Growing community of inventors

Shanghai, China

Xiu Wang