Jiangsu Kangbeide Pharmaceuticals Co. Ltd.

Xiquan Liu

Li Wang

Xiaoyan Shi

Li Song

XIaoyan Shi

Shuming Wang

Hongguang Du

Yucheng Lu

Xuying Zhong

Huiyong Xue

Enhong Zhang

Hongjun Lian

Guohua Chi

A Rotigotine-containing composition having a matrix mixture system formed from a polyvinylpyrrolidone and a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive. The polyvinylpyrrolidone may be present in an amount of about 1-10% by weight in matrix mixture system. The acrylic pressure-sensitive adhesive may be present in an amount of about 1-25% by weight in the matrix mixture system. The silicone pressure-sensitive adhesive may be present in an amount of about 65-98% by weight in the matrix mixture system. The composition further includes 1-40% of Rotigotine on the basis of the total weight of the composition. The composition provides improved properties in the solubility, release and initial penetration level of Rotigotine. Also disclosed is a transdermal patch that includes the Rotigotine-containing composition, as well as methods of manufacturing and using the Rotigotine-containing composition.

Transdermal patch containing Rotigotine

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Beijing, China

Xiquan Liu