Chemwerth, Inc.

Sunovion Pharmaceuticals Inc.

Xiping Su

Peter J Werth

Roger P Bakale

H Scott Wilkinson

Sidney Xi Liang

Zhengxu Han

Mark A Varney

Thomas Wessel

Judy Caron

Surendra Singh

Lin Yi

Stefan G Koenig

Karim Lalji

Wilkinson Scott

Stephan G Koenig

Surendra P Singh

Stephen G Koenig

The disclosure provides compounds and pharmaceutically acceptable salts thereof of Formula (I) The variables, R, R!-R3 and the A-ring are described herein. A can be a cyclohexyl ring. The compounds are inhibitors of JAK1 Kinase and are useful in methods of treating an allergic, inflammatory, or autoimmune disorders, in a patient, comprising administering a therapeutically effective amount of compound of Formula I or salt thereof, to the patient. The disclosure also provides pharmaceutical formulations containing a compound of Formula I.

Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl) amino compounds useful as JAK 1 inhibitors

Methods and intermediates for the synthesis of carprofen and its derivatives starting from cyclohexanone are disclosed.

Synthetic processes of carprofen

One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.

Process for preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1Napthalenamine

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Woodbridge, CT, United States of America

Xiping Su