Agency for Science, Technology and Research

Omeros Corporation

Institute of Materials Research and Engineering

Xiping Ni

Jun Li

Kam W Leong

Xu Li

Xian Jun Loh

Zhongxing Zhang

Described herein are copolymers comprising at least one first water-soluble monomeric unit, at least one second water-soluble monomeric unit, and at least one monomeric unit containing a basic residue.

Copolymers

A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent intimately contained within the hydrogel. In one preferred embodiment of the invention, the A polymer block is poly(ethylene oxide) (PEO) and the B polymer block is poly[(R)-3-hydroxybutyrate] (PHB), and the copolymer is the triblock ABA copolymer PEO-PHB-PEO. A method of synthesizing the amphiphilic triblock copolymer is also provided.

Biodegradable triblock copolymers, synthesis methods therefore, and hydrogels and biomaterials made there from

Growing community of inventors

Singapore, Singapore

Xiping Ni