Vicore Pharma Ab

Xiongyu Wu

Mathias Alterman

Anders Rudolf Hallberg

There is provided compounds of formula I, wherein A, X, X, X, X, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

Tricyclic angiotensin II agonists

There is provided compounds of formula I, wherein the dotted line, X, X, X, A, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

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Uppsala, Sweden

Xiongyu Wu