Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Xiongxiong He

Ping Dong

Jiahui Cai

Lei Liu

Xiquan Zhang

Rui Zhao

Xifeng Lu

Jiao Xu

Bo Jiang

Zhenxue Deng

Shanshan Sui

Xin Huang

The present application relates to the field of pharmaceutical technology, specifically to the crystal habit and crystalline powder preparation of quinoline derivatives, and more specifically, to the crystal habit and crystalline powder preparation of anlotinib dihydrochloride. The compound of formula II disclosed herein is a crystalline powder with a flaky crystal habit having a specific surface area &#x2265;10 m/g and a particle-size distribution of X&#x2264;50 &#x3bc;m and/or X&#x2264;500 &#x3bc;m, such that a large specific surface area is provided without reducing the particle size of the drug by a physical method under the condition of a broad particle-size distribution, and the drug can rapidly dissolving. In addition to excellent dissolution property, the crystalline powder is also beneficial to industrial manufacturing, featuring simplified process and cost-efficiency.

Crystal habit of quinoline derivative and preparation method for crystalline powder thereof

A pharmaceutical composition comprising dabigatran etexilate, and preparation method and use thereof, and solid preparation comprising the pharmaceutical composition; the pharmaceutical composition comprises a vitamin C layer and a dabigatran etexilate layer separated by a semipermeable film layer, and the semipermeable film layer comprises a water-soluble compound, a water-insoluble compound and an optional anti-sticking agent and/or plasticizer.

Pharmaceutical composition comprising dabigatran etexilate, and preparation method, solid preparation and use thereof

The present application provides a pharmaceutical composition comprising 6-(2-chloro-4-iodophenylamino)-N-(2-hydroxyethoxy)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridine-7-carboxamide or a pharmaceutically acceptable salt, a binder, a surface stabilizer and a dispersant, wherein the pharmaceutical composition can be dispersed in water to form a pharmaceutical suspension having a median particle size, X50, of 0.5 &#x3bc;m to 4.0 &#x3bc;m. Also disclosed are a preparation method thereof and the use thereof for treating cancers.

Pharmaceutical composition of MEK inhibitor and preparation method thereof

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Lianyungang, China

Xiongxiong He