Exxonmobil Chemical Patents Inc.

Schering Aktiengesellschaft

Linhai Tianyu Pharmaceutical Co., Ltd.

Shanghai Qixun Pharmaceutical Technology Co., Ltd.

Xiongdong Lian

Jian Yang

Matthew William Holtcamp

Peijun Jiang

Gregory S Day

Gary Bruce Phillips

Lubin Luo

Monica J Kochanny

Stefan Jaroch

Xuan Ye

Meina Liang

Bin Ye

Wenbo Wang

James Onuffer

Steven D Brown

Wheeseong Lee

Gongyong Li

Botao Li

Laura Dunning

Shou-Fu Lu

Guo-Ping Wei

Qianjie Yu

Kunlun Qiu

This invention relates bisindenyl metallocene catalyst compounds having long (at least 4 carbon atoms) linear alkyl groups substituted at the two position and substituted or unsubstituted aryl groups at the four position and process using such catalyst compounds, particularly in the solution process at higher temperatures.

Metallocene catalyst compositions and polymerization process therewith

Disclosed is a method for preparing a 2-fluoroacrylate, comprising the steps of: (1) mixing a vinyl ether having the structure of formula A with dichloromonofluoromethane to yield a substituted cyclopropane compound having the structure of formula B; (2) mixing the substituted cyclopropane compound having the structure of formula B with ROH to yield an acetal product having the structure of formula C, followed by hydrolysis to yield 2-fluoroacrylaldehyde having the structure of formula D; or reacting the substituted cyclopropane compound having the structure of formula B with water to yield 2-fluoroacrylaldehyde having the structure of formula D via hydrolysis; (3) oxidizing 2-fluoroacrylaldehyde having the structure of formula D to yield 2-fluoroacrylic acid having the structure of formula E; and (4) mixing 2-fluoroacrylic acid having the structure of formula E with ROH to yield a 2-fluoroacrylate having the structure of formula F.

Method for preparing 2-fluoroacrylates

The present disclosure relates to bridged metallocene catalysts that include at least one indenyl ligand substituted at the 2-position with a C-Cbranched alkyl, such as isopropyl. Catalyst systems including the catalysts, polymerization processes using the catalysts, and polymers made using the catalysts are also described.

Bridged bis(indenyl) transitional metal complexes, production, and use thereof

This invention relates to supported metallocene catalyst systems for polymerization, the catalyst systems comprising asymmetrically substituted indenyl groups, high surface area supports, and aluminoxane activators. This invention also relates to methods for polymerizing olefins, including methods for producing isotactic polypropylene.

Supported metallocene catalyst systems for polymerization

This invention relates to novel bridged bis indenyl metallocene catalyst compounds where the bridge is &#x2014;((R)Si&#x2014;Si(R))&#x2014; wherein, each Rand Ris identical or different and is a substituted or unsubstituted, branched or unbranched C-Calkyl group, preferably each Rtogether do not form a ring, and/or each Rtogether do not form a ring, and/or Rand Rtogether do not form a ring. This invention also relates to polymerization processes to produce polymer and to polymer compositions produced by the methods described.

Substituted bis indenyl metallocene catalyst compounds comprising-Si&#x2014;Si-bridge

The invention relates to a novel group bridged metallocene transition metal complexes, wherein the complex includes at least one indenyl ligand substituted at the 4-position with a phenyl group, the 4-phenyl group being preferably substituted at the 3', 4&#x2032;, and 5&#x2032; positions with particular combinations of substituents, particularly wherein the 4&#x2032;-substituent is a group of the formula (XR&#x2032;), wherein X is a Group 14-17 heteroatom having an atomic weight of 13 to 79 and R&#x2032; is one of a hydrogen atom, halogen atom, a C-Calkyl group, or a C-Caryl group and n is 0, 1, 2, or 3. Catalyst systems including the transition metal complex, polymerization processes using the transition metal complex, and polymers made using the transition metal complex are also described.

This invention relates to a novel group 4 transition metal metallocene catalyst compound that is asymmetric having two non-identical indenyl ligands with substitution at Rhaving a branched C-Calkyl group, Rhaving a linear alkyl group and Rand Rhaving substituted phenyl groups, where at least one of Rand Ris a phenyl group substituted at the 3 and 5 position.

Metallocenes and catalyst compositions derived therefrom

The present invention relates to CCR5 receptor antagonists of formulae (1) or (1): enantiomers, diastereomers, salts and solvates thereof wherein R, R, R, R, R, and Rare as defined herein. The invention further includes a method of CCR5-mediated disorders employing such compounds.

Substituted quinoline CCR5 receptor antagonists

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Shanghai, China

Xiongdong Lian