Mcmaster University

Xiong Zhang

Jakob Magolan

Mathew Piotrowski

Nicholas Jentsch

Eric Brown

Nicole Ritchie

Arnav Kaul

Nick Jentsch

Jarrod Johnson

Omar M Elhalfawy

Meghan Fragis

Patrick Darveau

Provided herein are novel synthetic compounds having the structure of formula (1), wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C-Calkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.

Synthetic antibacterial compounds and uses thereof

The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

Processes for the preparation of ortho-allylated hydroxy aryl compounds

The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I). 

Processes for the preparation of-allylated hydroxy aryl compounds

Growing community of inventors

Tianjin, China

Xiong Zhang