Acuitas Therapeutics, Inc.

Dermira (canada), Inc.

Alnylam Pharmaceuticals, Inc.

Kinetek Pharmaceuticals, Inc.

Valocor Therapeutics, Inc.

Dirmira (canada), Inc.

Olt Inc.

Xinyao Du

Steven Michial Ansell

Zaihui Zhang

Serguei Sviridov

Timothy Scott Daynard

Jianxin Chen

Shisen Wang

Gregory B Chopiuk

Jun Yan

Greg Chopiuk

Michael J Hope

Thomas D Madden

Barbara Mui

Christopher James Barbosa

Paulo Jia Ching Lin

Compounds are provided having one of the following structures (I) or (II): or (I) (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G2b and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids

Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.

Lipid nanoparticle formulations

Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R, R, L, L, G, Gand Gare as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Lipids and lipid nanoparticle formulations for delivery of nucleic acids

Compounds are provided having the following structure: [Formula should be inserted here] or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, L, L, G, Gand Gare as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided. 

Lipids for use in lipid nanoparticle formulations

Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R, R, R, R, R, R, R, R, R, R, R, R, L, L, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein G, G, G, G, G, L, L, L, L, X, X', Y and Y&#x2032; are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided. 

Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein X, Y, L, L, L, G, Gand Gare as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided. 

Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R, R, R, R, R, L, L, L, G, G, and Gare as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Lipids for lipid nanoparticle delivery of active agents

Compounds are provided having the following structure: Formula (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R, R, G, Gand n are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided. 

Lipids for delivery of active agents

Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R, R, R, R, R, R, R, R, R, R, R, R, L, L, G, G, G, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Growing community of inventors

Richmond, CA, United States of America

Xinyao Du