Wyeth

Xinxu Shi

Bogdan Kazimierz Wilk

Panolil C Raveendranath

Yanzhong Wu

Galina Vid

Jean Louise Helom

John Potoski

Zhixian Ding

Charles Chao Wu

Vladimir Dragan

Weiguo Liu

Wayne G McMahon

Haris Durutlic

Processes for preparing oxindoles, which can be utilized in the preparation of a variety of useful compounds, and methods for minimizing or preventing N-alkylation of amide containing compounds, including oxindoles, are provided. Also provided is a compound of the following structure: 

Process for the synthesis of progesterone receptor modulators

The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid, and esters thereof.

Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid and esters thereof

The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.

Processes and compounds for the preparation of substituted naphthylindole derivatives

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Xinxu Shi