Jiangnan University

Xinxin Sang

Caihua Ni

Gang Shi

Liping Zhang

Ren Liu

Dawei Wang

Ying Li

Jingguo Yang

Xuan Jin

Likui Wang

Jie Chen

Xiaofeng Xia

Yuanyuan Ding

Jianhua Li

Yongqin Zhao

Jiatao Miao

The invention presents a near-infrared photothermal coupling curing non-oxide ceramic slurry, along with its preparation method and application. The ceramic slurry consists of various raw materials, with weight fractions as follows: non-oxide ceramic powder (40˜90 parts), photosensitive resin (0.5˜20 parts), photosensitive monomer (1˜40 parts), photoinitiator (0.25˜4 parts), thermal initiator (0.25˜4 parts), additive (0.75˜5 parts), and up-conversion luminescent material (0.5˜4 parts). The non-oxide ceramic powders can include SiN, TiN, BN, AlN, SiC, WC, TiC, ZrC, TiB, and ZrB. By combining the photochemical and photothermal dual curing system using near-infrared up-conversion, this invention addresses the issue of insufficient curing encountered in single photocuring or thermal curing processes. Moreover, by incorporating near-infrared light source-driven additive manufacturing, it enables rapid prototyping of high-solid-content non-oxide ceramic slurry, ultimately allowing for the fabrication of high-fidelity non-oxide ceramic structures.

Near-infrared photothermal coupling curing non-oxide ceramic slurry and its preparation method and application

A method for making reduction sensitive nano micelles comprising: 1) dissolving taurine in distilled water, and adding sodium hydroxide solution; 2) dissolving acryloyl chloride in dichloromethane, reacting at 25&#xb0; C.; dissolving lipoic acid in toluene and adding hydroxyethyl methacrylate, reacting at 85&#xb0; C.; 3) dissolving N-acryloyltaurine and lipoic acid methacryloyloxyethyl ester and reacting at 60&#x2dc;65&#xb0; C., dropping the polymer solution into deionized water, adding dithiothreitol and reacting at 25&#x2dc;30&#xb0; C. to obtain reduction sensitive nano micelles after freeze-drying. The nano micelles have regular morphology and uniform distribution, and can be used as drug carriers for controlled release.

Method for making reduction sensitive nano micelles

The present invention discloses a bionic SERS substrate of a metal-based compound eye bowl structure, a construction method and application. The bionic SERS substrate of the metal-based compound eye bowl structure of the present invention consists of a metal bowl and a cone-shaped structure substrate in an ordered hierarchy manner. The metal bowl is of a continuously and closely arranged single-layer bowl structure. A height of the metal bowl is 0.01-10 &#x3bc;m, and a bowl opening diameter is 0.01-10 &#x3bc;m. A cone is a micron pyramid cone, and a height of the micron pyramid cone is 1-100 &#x3bc;m. The present invention assembles the metal bowl on a surface of the substrate of the micron pyramid cone structure with great fluctuation by a solid-liquid interface chemical reduction method and a small ball template method, and further constructs a 3D SERS substrate with a bionic compound eye structure.

Bionic SERS substrate with metal-based compound eye bowl structure and its construction method and application

The present invention discloses an SERS substrate of a metal-modified semiconductor-based bionic compound eye bowl structure and a construction method, and belongs to the technical field of nano materials. The present invention is based on a multi-time interface self-assembly method. Firstly, a small ball template is constructed by using a gas-liquid interface assembly process. Then, a semiconductor bowl structure array is induced to be formed by the template by using a solid-liquid interface assembly process. Next, a semiconductor bowl is assembled to a surface of a pyramid-shaped cone to form a bionic compound eye structure by using a transfer process. Finally, a surface of the bionic compound eye structure is modified with a layer of uniformly distributed metal particles by a physical deposition method or a chemical deposition method, thereby forming the SERS substrate of the metal-modified semiconductor-based bionic compound eye bowl structure.

SERS substrate of metal-modified semiconductor-based bionic compound eye bowl structure and construction method

The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of &#x3b3;-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(&#x3b3;-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

Method of preparing pH/reduction responsive polyamino acid zwitterionic nanoparticles

Disclosed is a preparation method for charge reversal and reversibly crosslinked redox-sensitive nanomicelles, falling within the technical field of biomedical materials. The method comprises: synthesizing thiocinamide from lipoic acid and ethylenediamine under an N,N'-carbonyl diimidazole catalyst; and polymerizing thiocinamide, polyethylene glycol diglycidyl ether and lysine through a nucleophilic addition mechanism to prepare a poly(lysine-co-polyethylene glycol diglycidyl ether-co-thiocinamide) terpolymer. The micelle is endowed with excellent anti-protein nonspecific adsorption and enhanced cell uptake property through a self-assembly and protonation/deprotonation action; and a disulfide bond in lipoyl may form a linear polydisulfide structure under the action of 1,4-dithiothreitol, so that a micelle core is crosslinked, and a crosslinked structure is destroyed in the cell under a redox condition, and controlled release of a drug can be achieved. The Nanomicelle of the present invention is expected to be a carrier of drugs for treating cancers.

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Wuxi, China

Xinxin Sang