Guangzhou Hc Pharmaceutical Co. Ltd

Institute of Medicinal Biotechnology, Chinese Academy of Medical

Chinese Academy of Medical Sciences

Xinxin Hu

Yang Chen

Yan Gao

Xi Lu

Zhuorong Li

Sheng Tang

Jie Jin

Xuefu You

Xiukun Wang

Yinghong Li

Danqing Song

Yanxiang Wang

Zhihao Guo

Zhiwen Li

Along Cui

Qiyang He

The present invention relates to a compound as shown in general formula (I) below (in formula (I), each of Rand Rindependently represents a hydrogen atom or a C1-10 linear or branched alkyl optionally having a substituent, or the two together form a cycloalkyl with 3 to 8 ring carbon atoms; each of Rand Rindependently represents a hydrogen atom or a C1-10 linear or branched alkyl optionally having a substituent or a C6-12 aryl optionally having a substituent, or the two together form a cycloalkyl with 3 to 8 ring carbon atoms; X represents C or N; and Y represents a linear or branched alkenyl or alkynyl with 2 to 6 carbon atoms and optionally having a substituent, or carboxyl). The compound has good antibacterial properties against bacteria, especially gram-negative bacteria, has low drug resistance, and has good prospects for the effective treatment of various conditions.

β-lactam compound, use thereof and preparation method therefor

Growing community of inventors

Beijing, China

Xinxin Hu