Columbia University

Cold Spring Harbor Laboratory

Xinwen Yao

Christine P Hendon

Michal Lipson

Xingchen Ji

Alexander Klenner

Yu Gan

Aseema Mohanty

Mohammad Amin Tadayon

Yuye Ling

Adam Kepecs

Qian Li

A method of providing optical coherence tomography (OCT) imaging may comprise using an on-chip frequency comb source interfaced with an OCT system by a circulator as an imaging source and reconstructing OCT images from resulting spectral data from target tissue illuminated by the imaging source.

Microresonator-frequency-comb-based platform for clinical high-resolution optical coherence tomography

Provided are devices that have a distal portion configured to be implanted in a brain of a subject. The distal portion includes one or more emitters configured to emit light in the visible spectrum. The device includes a proximal portion configured to be external to the brain of the subject while the distal portion is implanted, wherein the proximal portion includes at least one waveguide in optical communication with the one or more emitters. The at least one waveguide defines a cross-sectional width less than 500 nm. The at least one waveguide is optionally coupled to a heating element that is optionally configured to adjust a phase of light within the at least one waveguide.

Thermally tunable low broadband waveguides and related systems and methods

An exemplary system can be provided which can include, for example, a plurality of source arrangements configured to provide a plurality of electro-magnetic radiations to at least one of at least one sample or at least one reference structure, a first arrangement configured to receive a first radiation(s) from the reference structure(s), a second arrangement configured to receive a second radiation(s) from the sample(s), where a portion(s) of the second radiation(s) can be in an invisible spectrum, a third arrangement configured to combine the first radiation(s) and the second radiation(s) into a third radiation(s), and a fourth arrangement configured to convert the third radiation(s) into a further radiation in a visible spectrum based on the at least one portion.

High-sensitive swept-source optical coherence tomography system and methods of use thereof

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Xinwen Yao