Abmaxis, Inc.

Merck Sharp + Dohme Corp.

Xinwei Wang

Pingyu Zhong

Caili Wang

Yan Li

Peter Peizhi Luo

Shengfeng Li

Feng Dong

Andrei Alexandrovich Golosov

Peizhi Luo

Rose M Cubbon

Laurence B Peterson

Mark Hsieh

Weirong Wang

Yan Ni

Shengjiang Liu

Kevin Caili Wang

Jon H Condra

Kevin Caili Wangr

Sujata Sharma

Jun Lu

Gopalakrishnan Parthasarathy

Stephen Soisson

Noel Byrne

Antagonists of human proprotein convertase subtilisin-kexin type 9 ('PCSK9') are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

AX132 PCSK9 antagonists

AX1 PCSK9 antagonists

The present invention provides adapter-directed display systems for expressing exogenous polypeptide within a host cell and/or displaying the exogenous polypeptide on the outer surface of a genetic package. This subject systems are particularly useful for displaying a genetically diverse repertoire of monomeric and multimeric polypeptides. The invention also provides both expression and helper vectors and kits containing components of the subject display systems. Also provided are genetic packages displaying the exogenous polypeptides of particular interest. Further provided by the invention are methods of using the subject display systems.

Adaptor-directed helper systems

The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.

Compositions and methods for generating chimeric heteromultimers

Adapter-directed display systems

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San Jose, CA, United States of America

Xinwei Wang