Senomyx, Inc.

Xinshan Kang

Xiaodong Li

Catherine Tachdjian

Albert Zlotnik

Guy Servant

Qing Chen

Xiao-Qing Tang

Richard Masten Fine

Boris Klebansky

Feng Zhang

Marketa Rinnova

Mark Zoller

Sara Werner

Donald Karanewsky

Vincent Darmohusodo

Hong Zhang

Haitian Liu

Joseph R Fotsing

Sara L Adamski-Werner

Jeffrey Robert Hammaker

Goran Petrovic

Jeffrey Yamamoto

Rachel D A Kimmich

Donald S Karanewsky

Rachel Da Kimmich

Sara Adamski-Werner

Rachel DA Kimmich

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Modulation of chemosensory receptors and ligands associated therewith

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

The present invention provides, in part, substituted thieno[2,3-d]pyrimidines and methods of contacting compositions with such compounds to enhance the sweet taste of said compositions.

Methods of enhancing sweet taste of compositions using substituted thieno{2,3-D}pyrimidines

The present invention provides compounds including substituted thienopyrimidinone derivatives of Formula (IIc) as ligands for modulating chemosensory receptors: These compounds are useful as sweet taste enhancers in comestible or medicinal compositions. The present invention also provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors

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Pine Brook, NJ, United States of America

Xinshan Kang