University of Delaware

William Marsh Rice University

Xinqiao Jia

Mary C Farach-Carson

Joseph M Fox

Amit Kumar Jha

Colin Thorpe

Yixin Xie

Yinzhi Fang

Daniel A Harrington

Joel Rosenthal

Han Zhang

Robert L Witt

Swati Pradham Bhatt

Will Trout

Shuang Liu

Catherine E Safran

Padma P Srinivasan

A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein one R group on the dihydrotetrazine 1 is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the other R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl,- or heteroatom-containing groups; 1, 2 wherein the method comprises oxidizing dihydrotetrazine 1 in a reaction medium in the presence of a catalyst and a stoichiometric oxidant. 

Methods for inducing bioorthogonal reactivity

Implantable modular hydrogels to aid in salivary gland restoration and associated methods are provided. In one embodiment, the present disclosure provides for a hydrogel network comprising: a hyaluronic acid macromer crosslinked with a multiblock copolymer.

Implantable modular hydrogel for salivary gland restoration

A method for enhancing chondrogenesis in a subject in need thereof comprises administering to the subject an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles (HGPs). The hyaluronic acid (HA)-based hydrogel particles (HGPs) are conjugated with a heparan sulfate proteoglycan (HSPG). Related medicaments and methods for preparing the medicaments are provided.

Injectable delivery system for heparan-binding growth factors

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Newark, DE, United States of America

Xinqiao Jia