Jacobio Pharmaceuticals Co., Ltd.

Xinping Wu

Cunbo Ma

Panliang Gao

Di Kang

Shaojing Hu

Jinlong Bai

Huifeng Han

Zilong Xu

Chunwei Wen

Xiaoyan Pei

Jie Chu

This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder. 

Heterocyclic derivatives useful as SHP2 inhibitors

Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder. 

Heterocyclic ring derivatives useful as SHP2 inhibitors

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Beijing, China

Xinping Wu