The University of Texas System

University of Illinois

Xinpeng Ma

Jinming Gao

Gang Huang

Yang Li

Baran D Sumer

Yiguang Wang

Tian Zhao

Paul Joseph Hergenrother

David A Boothman

Elizabeth I Parkinson

Joseph S Bair

Lifen Cao

Xiumei Huang

Xiuquan Luo

Zachary R Moore

Qi Wei

Yuliang Liu

Jimming Gao

Paul J Hergenrother

The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

Library of pH responsive polymers and nanoprobes thereof

Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R, R, R, R, R, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer. 

Naphthoquinones, pro-drugs, and methods of use thereof

The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective legality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

Tumor-selective combination therapy

The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

Growing community of inventors

Dallas, TX, United States of America

Xinpeng Ma