Novartis Ag

Alcon, Inc.

Alcon Research, Ltd.

Xinming Qian

Daqing Wu

Frank Chang

Yongxing Qiu

John Dallas Pruitt

Jared Nelson

Lynn Cook Winterton

Arturo Norberto Medina

Newton T Samuel

Chandana Kolluru

Steve Yun Zhang

Zach Munoz

Ying Zheng

Richard Charles Breitkopf

Augustine Twum Kumi

Matthew D Nelson

Feng Jing

Weihong Lang

Troy Vernon Holland

Junhao Ge

Venkat Shankar

Yasuo Matsuzawa

Joseph Michael Lindacher

Angelika Maria Domschke

Robert A Scott

Dawn A Smith

Uwe Haken

Richard Charles Turek

Jürgen Vogt

Robert Carey Tucker

Chung-Yuan Chiang

Kelly Kayi Tallau

Leroy Wainaina Muya

Wei Liang

Ritu Shrestha

Dharmesh Patel

The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

Silicone hydrogel lens with a crosslinked hydrophilic coating

The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

Silicone hydrogel contact lenses

The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40&#xb0; C. to about 140&#xb0; C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.

Soft silicone medical devices

The present invention generally relates to a method for producing inherently wettable silicone hydrogel contact lenses with a robusteness of lens shape and having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus.

Method for producing silicone hydrogel contact lenses

The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.

Soft silicone medical devices with durable lubricious coatings thereon

The present invention generally relates to a method for producing silicone hydrogel contact lenses having a stable lubricious coating thereon without involving use of organic solvent in post-curing processes.

Method for applying stable coating on silicone hydrogel contact lenses

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Johns Creek, GA, United States of America

Xinming Qian