Thrombosis Research Institute

Trigen Gmbh

Xinjie Lu

Vijay Vir Kakkar

Michael Finbarr Scully

Kalwant S Authi

The invention relates to multiple epitope constructs, immunogenic and vaccine compositions comprising recombinant molecules presenting inserted multiple and different epitopes from a variety of antigens. The antigenic determinants being associated with different pathways leading to atherosclerosis. In particular, the invention relates to such compositions for eliciting an immune response against antigens and pathogens involved in the development of atherosclerosis the invention includes intermethods of treating and/or preventing the disease and recombinant protein products.

Multi-epitopic construct

The invention relates to a recombinant protein comprising: a carrier portion; a first epitope capable of eliciting an anti-atheroma response; and a second epitope capable of eliciting an anti-atheroma response, characterized in that said first and second epitopes are distinct from one another.

Anti-atheroma vaccine

Dendroaspin, a polypeptide neurotoxin analogue is modified by recombinant DNA techniques, particularly &ldquo;loop grafting&rdquo; to provide a modified polypeptide. The modified polypeptide is constructed so as to retain dendroaspin activity, for example, platelet adhesion to fibrinogen, in addition to possessing one or more further biological or biochemical activities not native to dendroaspin, for example, platelet derived growth factor (PDGF) activity or hirudin activity.

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London, United Kingdom

Xinjie Lu