Covidien LP

Alnova Pharmaceuticals, Ltd.

Xini Zhang

Syed Sarfraz Ahamed

Jiangfeng Zhang

Manojit Hazra

Thomas R Hessler

Tao Hu

Shunhong Xu

Ping Ren

Sridharan Varadhan

Zhinan Guo

Jeevan Shankar Setty Maddur

Zhigang Xiong

Shaohui Shi

A surgical stapling device includes a removable or releasable cartridge assembly. The surgical stapling device and the cartridge assembly include engagement members for releasably securing a thrust bar of the stapling device to a knife assembly of the cartridge assembly. The stapling device also includes structure to prevent the knife assembly from being disengaged from a cartridge body of the cartridge assembly and for obstructing advancement of the knife assembly within the cartridge body after the stapling device has been fired.

Surgical stapling device with reloadable cartridge

A surgical stapling instrument includes an elongate body portion defining a longitudinal axis, and an end effector supported on a distal portion of the elongated body portion. The end effector includes a housing having a base portion and a jaw portion, an anvil assembly supported on the jaw portion, and a cartridge assembly releasably supported on the base portion. A tissue guide member is operably secured relative to the cartridge assembly to facilitate alignment of the cartridge assembly through a firing stroke.

Tissue guide for curved end effectors

A surgical stapling device () includes a replaceable cartridge assembly () having knife assembly () and an anvil assembly () including a cutting plate (). The cutting plate () is configured be durable to maintain performance of the stapling device () over multiple firings.

Anvil assembly with cutting plate

A surgical stapling device includes an anvil assembly and a replaceable cartridge assembly. The cartridge assembly includes a knife blade and upper and lower alignment pins for retaining tissue between anvil and cartridge assemblies to ensure that the knife blade cuts cleanly through tissue. The cartridge assembly includes a cartridge body having guide structure for guiding the cartridge assembly onto a clamp slide assembly of the stapling device.

Stapling device with cartridge assembly with alignment pins

A surgical stapling device includes a tool assembly having a U-shaped frame, an anvil assembly, and a cartridge assembly. The U-shaped frame has a proximal transverse portion, a longitudinal portion, and a distal transverse portion. The distal transverse portion and the proximal transverse of the U-shaped frame and the cartridge assembly have a common shape including a first linear portion defining a first axis, a second linear portion defining a second axis, and a third linear portion defining a third axis, the first axis being transverse to the longitudinal axis of the elongate body. In embodiments, a first radius of curvature is defined between the first linear portion and the second linear portion such that the first axis and the second axis define an angle &#x3b2;, and a second radius of curvature is defined between the second linear portion and the third linear portion such that the second axis and the third axis define an angle &#x3a9;.

Surgical stapling device with curved tool assembly

The present invention relates to an amorphous form of Idelalisib and its methods of preparation. Using a Cu-K&#x3b1; radiation, the X-ray powder diffraction (XRPD) pattern does not contain sharp diffraction peaks at a diffraction angle expressed in degrees 2&#x3b8;, and the X-ray powder diffraction pattern is shown in FIG.. The present invention also provides a preparation method for the amorphous form of Idelalisib. The amorphous form of Idelalisib of the present invention increases the solubility of Idelalisib and improves bioavailability of the drug product. As compared to the existing crystalline forms of Idelalisib, its solubility increases significantly, which improves body's absorption of the drug and makes it more efficacious in the clinical therapeutic treatment of diseases. Under the stress test conditions, the amorphous material can maintain good physical and chemical stabilities. The preparation method of amorphous Idelalisib according to the present invention is simple to operate and easy to implement.

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Shanghai, China

Xini Zhang