Beijing Forelandpharma Co. Ltd.

Foreland Pharma Co., Ltd.

Beijing Foreland Biopharma Co., Ltd.

Broadenbio Co., Ltd.

Xingmin Zhang

Lei Wang

Qi Ji

Zhenjian Du

Congmin Gao

Longlong Gong

Ensi Wang

Bo Chen

Qi Wang

Jing Guo

Wei Hua

Nan Zheng

Shengxiu Niu

Zhuolin Dai

Liping Ji

Zhenfang Wang

Tie Liang

Meijing Du

Gongping Duan

Provided are a compound of formula (I), or a pharmaceutically acceptable salt, solvate, active metabolite, polymorph, isotopic label, isomer or prodrug thereof, and a use thereof. The above-mentioned compound has a very strong inhibitory effect on the FGFR4 kinase activity and the proliferative activity of Hep 3B cells with high FGFR4 expression.

Bridged cycloformylpyridine derivatives and uses thereof

The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present invention also discloses a pharmaceutical composition comprising the above substances, and a use of the substance in the preparation of a medicament for the prevention and treatment of an immune inflammatory disease, or a disease or condition associated with immunological competence such as multiple sclerosis, ALS, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis, polymyositis, etc.

Amino alcohol derivative, pharmaceutical composition and application thereof

The present invention relates to the crystal form of imidazolone type compounds, and a preparation method, pharmaceutical composition and use thereof, and falls within the field of pharmaceutical compound crystals. The crystal form provided by the present invention has a good stability, comprising good stability under the three extreme conditions of high temperature, high humidity and strong illumination, and can also maintain a good stability during the tablet compressing process. The crystal form provided by the present invention has good absorption and metabolism properties in vivo, comprising the drug concentration of blood, the drug concentration-time curve AUC, the half-life period, etc. In addition, the dissolving rate of the crystal form of the present invention is improved, wherein same is beneficial for the applications thereof in preparations.

Crystal form of imidazolone type compounds, and preparation method, pharmaceutical composition and use thereof

This application relates to imidazolone compounds, pharmaceutically acceptable salts, solvents, polymorphs or prodrugs thereof, and further relates to pharmaceutical combinations comprising the foregoing substances and uses for preventing and treating protein kinase related diseases such as cancer, metabolic diseases, and cardiovascular diseases.

Imidazolone derivatives, pharmaceutical compositions and uses thereof

The present invention provides a heterocyclic group contained amino-methanol derivative, and salt, a preparation method and use thereof, and belongs to the medical field. The heterocyclic group contained amino-methanol derivative and the salt thereof of the present invention are used for preparing medicines for immune suppression and for the treatment of organ transplant rejection, or medicines for treating immune mediated inflammatory diseases, such as multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis.

Heterocyclic group contained amino-methanol derivative, and salt, synthetic method and use thereof

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Beijing, China

Xingmin Zhang