Ceribell, Inc.

Leland Stanford Junior University

Xingjuan Chao

Josef Parvizi

Raymond Woo

Alexander M Grant

Bradley G Bachelder

Jianchun Yi

Vahid Saadat

Mathew A Herron

Ronald C Eddington, Jr

Christopher D Chafe

Chris Chafe

Baharan Kamousi

Mehdi Hajinoroozi

Suganya Karunakaran

Brad G Bachelder

Jianchum Yi

A handheld device for sonifying electrical signals obtained from a subject is provided. The device can utilize at least one of several operations including (but not limited) digitizing signals from electrodes, adjusting the signals based on accelerometer input, filtering the signals, conditioning the signals according to conditioning parameters, modulating the signal according to sound synthesis parameters, and generating sound from the representations of the signals to accomplish sonification. The device can include an analog-to-digital (A/D) converter to digitize the one or more electrical signals and a processor that receives the one or more digitized electrical signals and produces a representation of an acoustic signal. The device further includes a speaker system that sonifies the representation of the acoustic signal.

Handheld or wearable device for recording or sonifying brain signals

An electrode carrier system includes one or more electrode assemblies having an electrode body. One or more tubular members extend from the electrode body and define a lumen terminating in a distal opening. The electrode assemblies carry a reservoir containing a conductive fluid or gel. The reservoir is in fluid communication with the lumens in the tubular members, and the electrode assemblies are typically supported on a backing which may optionally be configured as a headband. Systems are for tracking patient movement may be used in combination with the electrode carrier system.

Methods and apparatus for electrode placement and tracking

The present disclosure provides systems, apparatuses, and methods for use of wearable electrode assemblies. The electrode assemblies improve comfort by providing increased overall surface area of their bottom surfaces, which make contact with the patient's scalp and hair. Collapse, compression, or telescoping of the bottom surface will thereby decrease the direct force and/or pressure applied by the distal member or members of the bottom surfaces to the skin. This may be advantageous in patients who have little to no hair in electrode contact areas, patient populations that are particularly skin-sensitive, and/or patients which must wear the electrode assemblies of an extended time period. The electrode assemblies further include structures to dispense and/or maintain conductive gel placed over the patient's skin, thereby maintaining electrical connection quality, and/or to facilitate the clearing of skin and/or hair prior to establishing an electrical connection.

Adjustable geometry wearable electrodes

Systems, devices, and methods are provided to assess connection quality between the electrodes of a bioelectrical signal measurement and/or electrical stimulation device and the tissue, typically skin, of the subject. A test signal is provided to a first electrode, voltage differences between the first electrode and additional electrodes are determined, an impedance of the first electrode is determined based on the voltages differences, and the determined impedance indicates connection quality. This process is typically repeated for all of the electrodes to determine connection quality. The user or subject can be alerted if the connection quality is poor, and the bioelectrical signal that is recorded can be provided with data points indicating connection quality during the signal recording.

Connection quality assessment for EEG electrode arrays

Systems and methods for sonifying electrical signals obtained from a living subject, particularly EEG signals, are disclosed. A time-domain signal representing the activity of an organ is obtained. A voltage of the time-domain signal over a time block is determined. An acoustic signal based on the time-domain signal over the time block is produced. The acoustic signal comprises one or more audibly discernible variations representative of the activity of the organ. If the determined voltage is over a threshold voltage, the time-domain signal is squelched over at least a portion of the time-block as the acoustic signal is produced. The time-domain signal can be squelched by ramping down the signal as an input to produce the acoustic signal. The frequency spectrum of the acoustic signal can also be adjusted as it is produced, such as by flattening the signal and/or attenuating high frequencies along the frequency spectrum of the signal.

Systems and methods for processing sonified brain signals

The present disclosure provides systems and methods for seizure detection. The method for seizure detection may include receiving a plurality of electroencephalography (EEG) signals over a plurality of channels for a subject, preprocessing the plurality of EEG signals by segmenting the plurality of EEG signals for each channel into a plurality of temporal data segments, extracting a plurality of features from each temporal data segment for each channel, and applying a machine learning algorithm to the plurality of features to perform a seizure binary classification for each temporal data segment for each channel. A control policy may be employed to determine a seizure burden on the aggregated seizure binary classifications. When the seizure burden is equal to or exceeds a threshold, a notification may be generated. The notification may be usable by a healthcare practitioner to assess whether the subject may be at risk of having a seizure.

Systems and methods for seizure prediction and detection

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Palo Alto, CA, United States of America

Xingjuan Chao