Nitto-Denko Corporation

Xinghe Wang

Lei Yu

Gang Zhao

Sang Van

Zhongling Feng

Zheng Hou

Yucheng Song

Yi Jin

Chieko Kitaura

Jian Liu

Xiaoli Fu

Fu Chen

Sanjib Kumar Das

Chris Castello

Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

Polyglutamate-amino acid conjugates and methods

Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

Compositions that include a hydrophobic compound and a polyamino acid conjugate

Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.

Guanidinium delivery carriers

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San Diego, CA, United States of America

Xinghe Wang