Georgia Tech Research Corporation

University of Georgia Research Foundation, Inc.

Children's Healthcare of Atlanta, Inc.

Emory University

Georgia State University Research Foundation, Inc.

Georgia State Research Foundation

Xinghai Ning

Geert-Jan Boons

Niren Murthy

Margaretha Wolfert

Jun Guo

Barbara Dale Boyan

Christopher Douglas Hermann

Zvi Schwartz

Robert Guldberg

David Scott Wilson

Tamim Diab

Mark M Goodman

Eric Seth Gilbert

Bryan Stubblefield

Seungjun Lee

Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.

Polymer hydrogels for in vivo applications and methods for using and preparing same

This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.

Oligosaccharide conjugates for targeting bacteria and uses related thereto

1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.

Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds

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Athens, GA, United States of America

Xinghai Ning