Academy of Military Medical Sciences

Celsion Corporation

Xingguo Mei

Yang Yang

Wei Gong

Chunsheng Gao

Meiyan Yang

Zhiping Li

Yuli Wang

Qingwei Jiang

Fanglin Yu

Weiping Yu

Zhenbo Yang

The present invention relates to a protein particle with a poorly water-soluble drug encapsulated therein and a preparation method therefor. The preparation method comprises the following steps: i) dissolving a poorly water-soluble drug and a liquid solubilizer into a good solvent; ii) partially or fully removing said good solvent from the product of step i); iii) mixing the product of step ii) with a protein; and iv) dispersing the product of step iii) in a poor solvent. The preparation method is simple and is suitable for industrial production.

Protein particle with a poorly water-soluble drug encapsulated therein and preparation method thereof

A thermosensitive liposome for the delivery of active agents and a composition thereof are disclosed, wherein the liposome comprises at least one phosphatidylcholine, at least one phosphatidylglycerol and at least one lysolipid, and the gel to liquid phase transition temperature of said liposome is from 39 0&#xb0; C. to 45&#xb0; C.

Thermosensitive liposomes containing therapeutic agents

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Beijing, China

Xingguo Mei