Sichuan University

Shanxi Jinbo Bio-pharmaceutical Co., Ltd.

Xingdong Zhang

Li Yang

Yunbing Wang

Rifang Luo

Xia Yang

Lu Lu

An anti-thrombotic and endothelialization-enhanced bioprosthetic valve material and preparation thereof are provided. The preparation method includes the following steps: immersing a glutaraldehyde cross-linked bioprosthetic valve material in functional reagent solution for 1-24 h, adjusting pH value of the solution to 3-8, removing it from solution and cleaning with deionized water. The new valve material of the present invention can effectively reduce the toxicity and side effects of the existing glutaraldehyde cross-linked bioprosthetic valve material and effectively reduce thrombosis, along with enhanced endothelialization. The material prepared can be used for pulmonary valve, aortic valve, mitral valve, tricuspid valve, venous valve and other cardiovascular implantable medical devices.

Anti-thrombotic and endothelialization-enhanced bioprosthetic valve material and preparation method thereof

A recombinant human collagen-based multifunctional stent coating and a preparation method thereof are provided. The preparation method includes (1) activating a substrate material; (2) placing the activated substrate material in an amino compound-containing solution for a reaction to obtain an aminated substrate material; (3) placing the aminated substrate material in a polyanion electrolyte solution for a reaction, and cleaning with deionized water. The recombinant human collagen-based multifunctional stent coating prepared by the present invention effectively improves the anticoagulation and rapid endothelialization performance of biomaterials, such as vascular stent materials, and reduces the late thrombosis and restenosis problems existing in current stent materials.

Recombinant human collagen-based multifunctional stent coating and preparation method thereof

Growing community of inventors

Chengdu, China

Xingdong Zhang