California Institute of Technology

Johns Hopkins University

Geneohm Sciences, Inc.

Northwestern University

The Scripps Research Institute

Aclara Biosciences, Inc.

Epic Sciences, Inc.

Geneohn Sciences, Inc.

Xing Yang

Yu-Chong Tai

Martin Gilbert Pomper

Sangeeta Ray

Ronnie Charles Mease

Charles I Grosjean

Ying Chen

Xuan-Qi Wang

Steven M Rowe

Michael T McMahon

Xiaolei Song

Sridhar Nimmagadda

Stephanie Slania

Thomas J Meade

John R Stuelpnagel

Dena Marrinucci

Ting Chen

Stephen L Mayo

Amish Desai

Il Minn

Hung Pin Kao

Peter Kuhn

R Erik Holmlin

Matthew W Rotz

Tze-Jung Yao

Mohamad Allaf

Michael Gorin

Elaine Marzluff

Dirk Bockenkamp

Joshua Kunken

Anand Kolatkar

Matthew Rotz

Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α) and their use in imaging and treating FAP-α related diseases and disorders are disclosed.

Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α)

Imaging and radiotherapeutics agents targeting fibroblast-activation protein-alpha (FAP-alpha)

Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.

Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy

Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.

Triazole conjugated ureas, thioureas, carbamates, and reversed carbamates for PSMA-targeted imaging agents and uses thereof

Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.

Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase IX and uses thereof

Salicylic acid-based polymeric CEST contrast agents targeting prostate-specific membrane antigen, pharmaceutical composition comprising the same and methods of use thereof are disclosed.

Salicylic acid-based polymeric CEST contrast agents targeting prostate-specific membrane antigen and uses thereof

Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

Metal/radiometal-labeled PSMA inhibitors for PSMA-targeted imaging and radiotherapy

The invention provides seminal computational approaches utilizing data from non-rare cells to detect rare cells, such as circulating tumor cells (CTCs). The invention is applicable at two distinct stages of CTC detection; the first being to make decisions about data collection parameters and the second being to make decisions during data reduction and analysis. Additionally, the invention utilizes both one and multi-dimensional parameterized data in a decision making process.

Method of using non-rare cells to detect rare cells

Compositions and methods for chemical exchange saturation transfer (CEST) based magnetic resonance imaging (MRI) or frequency labeled exchange (FLEX) imaging are disclosed. Beta-hydroxycarboxylate and beta-aminocarboxylate derivatives including salicylic acid, salicylates, salicylic acid prodrugs, N-alkyl/aryl/acyl/sulfonyl-anthranilic acid analogs, and any aromatic compound with OH/NH group ortho to the carboxylic acid group are disclosed. Such compounds can be used as general MRI organic contrast agents and produce significantly improved contrast in MR images detectable through CEST or FLEX.

Compositions and methods for chemical exchange saturation transfer (CEST) based magnetic resonance imaging (MRI)

Multiplexed analysis of molecular structures of samples. A plurality of sample wells is arranged on a substrate. A plurality of electrodes is fabricated on a first side of the substrate. The electrodes are disposed on the side of the substrate exposed to the sample wells. The electrodes include working electrodes, counter electrodes, and optionally include reference electrodes. At least two of the sample wells includes a plurality of working electrodes. The plurality of electrodes is configured to allow electrochemical analysis of the associated sample wells in a multiplexed fashion. The plurality of electrodes is electrically coupled to an interface to a sample analysis system. The interface to the sample analysis system can include contacts or connections. The sample analysis system controls a signal to the electrodes in a multiplexed fashion and performs the electrochemical analysis.

Multiplexed electrochemical detection system and method

Methods for conducting an assay to detect nucleic acid hybridization are disclosed. In particular, the fabrication of a carbon electrode suited to nucleic acid hybridization detection is described. In some preferred embodiments, a micro array of carbon electrodes is constructed using photolithography. The final step in the photolithography process involves developing a solder mask with an alkaline solution. The alkaline solution oxidizes the carbon surface producing surface carboxylic acid groups. The surface carboxylic acid groups are reacted with EDC or DCC and NHS to produce NHS esters. Immobilization of NEUTRAVIDIN&#xae; onto the electrode surface is effected by reaction with the surface NHS ester groups. A biotinylated probe DNA molecule is then attached to the electrode via binding between the biotin group and the immobilized NEUTRAVIDIN&#xae;. The resulting electrode can be used to detect hybridization between the probe DNA and complementary target DNA.

Carbon electrode surface for attachment of DNA and protein molecules

A method is provided for making a molecularly smooth surface, preferably on an electrode of an assay chip. This is desirable because it allows molecules, preferably oligonucloetides, to attach to the electrode surface with greater reliability and packing density than was previously available. Such attachment of molecules to an electrode surface is of particular interest in the field of electrochemical genetic analysis.

Method for making a molecularly smooth surface

Devices are provided comprising reflecting channels for directing horizontally a vertical light beam through a multiplicity of streams. The devices provide particular applications in microfluidics, where streams of narrow cross-sectional dimensions are involved. Desirably, channels having 45&#xb0; walls are provided for directing the beams and where the streams are divided by walls, the walls are at substantially 90&#xb0;. Methods of fabrication of the devices are provided.

Side light activated microfluid channels

Growing community of inventors

San Diego, CA, United States of America

Xing Yang