Intel Corporation

Affymetrix, Inc.

Ampliwise Inc.

Ms^2 Inc.

Manta Medtech LLC

Xing Su

Kai Wu

Mineo Yamakawa

Selena Chan

Tae-Woong T Koo

Lei B Sun

Grace M Credo

David J Liu

Andrew A Berlin

Jingwu Zhang

Oguz Hasan Elibol

Noureddine Tayebi

Jonathan S Daniels

Rui Mei

Kenneth B Swartz

Giulia C Kennedy

Hajime Matsuzaki

Liming Wang

Sean Walsh

Handong Li

Jianquan Liu

Mindy Su

Qing Ma

Mark F Oldham

Richard O Jones

Steven A Sundberg

Shoulian Dong

Jacque H Georger, Jr

Narayanan Sundararajan

David Eric Schwartz

Raju S Dave

Himanshu Verma

Valluri Ramana Rao

David J Lockhart

Yuegang Zhang

Narayan Sundararajan

Rolfe C Anderson

Gabi Neubauer

Steven J Kirch

Mark B Roth

Yanxiang Cao

Thomas B Ryder

Helin Dong

Sarah M Ngola

Weiwei Liu

Val M Dubin

Kenneth Schwartz

Tac-Woong Koo

Madoo Varma

Drew Hall

Palamadai Venkatraman

Zhang Jingwu

An embodiment relates to an active implantable medical device (AIMD), comprising: a permeability module that allows ingress flow of a fluid to an osmotic agent chamber and generates osmotic pressure; a piston that moves longitudinally within the active implantable medical device (AIMD) in response to the osmotic pressure; a drug chamber that comprises a drug and a valve module to allow one-way flow of the drug from the drug chamber to outside the active implantable medical device (AIMD); a sensor module that measures a displacement of the piston in real-time; and an electronic module that communicates a signal to the valve module to control the valve module and regulate the one-way flow of the drug based on the displacement of the piston.

Implantable device having piston displacement monitoring

An embodiment relates to an active implantable medical device (AIMD) comprising: a permeability module to allow ingress of a fluid into an osmotic agent chamber of the AIMD, a compressible piston, a drug chamber comprising a drug or being provided to receive a drug and a valve module to allow flow of the drug from the drug chamber to outside the AIMD through one or more drug outlets present in the AIMD, wherein the AIMD has dimensions that allow the AIMD to be implanted, subcutaneously, in a human body.

Active implantable medical device (AIMD) system for drug delivery with fixed dose size

A database comprising a digital signature of a smell, the digital signature comprising a smell data, the smell data comprising a response signal that is a function of a first data corresponding to a generator generating the response signal and a second data corresponding to a predetermined stimulus for generating the response signal, wherein the digital signature comprises binary data, wherein the response signal is a measurable response of the generator to the predetermined stimulus that is a function of change in electrical properties of resistance or impedance in the generator. wherein the generator generating the smell-related response signal is a Metal Oxide Semiconductor (MOS) in a sensor or a sensor pixel of a sensor array having a plurality of MOS sensor pixels having an MOS active material exposed to an analyte in the gas environment and the predetermined stimulus is a sequence of predetermined temperatures.

Systems and methods for generating smell data and a database thereof

An embodiment relates to system comprising: (i) a reaction mixture comprises: a) a target nucleic acid molecule; b) a forward primer complementary to a strand of the target nucleic acid molecule, the forward primer comprises a first molecular moiety at a 3' end, wherein the first molecular moiety is non-complementary to the strand of the target nucleic acid molecule; c) a reverse primer complementary to a complementary sequence of the strand of the target nucleic acid molecule, the reverse primer comprises a second molecular moiety at a 3&#x2032; end, wherein the second molecular moiety is non-complementary to the complementary sequence of the strand of the target nucleic acid molecule; d) a polymerase with 3&#x2032;-5&#x2032; exonuclease activity; and (ii a device suitable of detecting an amplification products.

Compositions and methods for nucleic acid amplification

Devices, methods, and systems for encoding data as DNA are provided. An encoder device can include circuitry to encode a data file having a bit sequence encoding data and to generate a virtual DNA (VDNA) sequence of virtual nucleotide bases (Vnb) that reversibly encodes the bit sequence of the data file, divide the VDNA sequence into a plurality of VDNA fragments, associate each VDNA fragment with an archive library sequence (Arc_SEQ), and generate a read instruction (READ) sequence of differences between each VDNA fragment and each associated Arc_SEQ including sufficient instruction to facilitate regeneration of each VDNA fragment from each associated Arc_SEQ. A codeword sequence (Code_SEQ) is additionally generated for each VDNA fragment that includes a codename identifying the associated Arc_SEQ, the READ sequence associated with the VDNA fragment, and an index sequence (Idx_SEQ) including an index mapping of the VDNA fragment in the VDNA sequence.

Data storage based on encoded DNA sequences

The disclosure provides compositions and methods for amplifying and/or analyzing nucleic acids.

Devices, methods, and systems for encoding data as DNA are provided. An encoder device can include an encoder engine configured to encode a data file having a bit sequence encoding data and further configured to generate a virtual DNA (VDNA) sequence of virtual nucleotide bases (Vnb) that reversibly encodes the bit sequence of the data file, divide the VDNA sequence into a plurality of VDNA fragments, associate each VDNA fragment with an archive library sequence (Arc_SEQ), and generate a read instruction (READ) sequence of differences between each VDNA fragment and each associated Arc_SEQ including sufficient instruction to facilitate regeneration of each VDNA fragment from each associated Arc_SEQ. A codeword sequence (Code_SEQ) is additionally generated for each VDNA fragment comprising a codename identifying the associated Arc_SEQ, the READ sequence associated with the VDNA fragment, and an index sequence (Idx_SEQ) including an index mapping of the VDNA fragment in the VDNA sequence.

The disclosure provides compositions and methods for amplifying nucleic acids.

DNA synthesis devices, systems, and methods are disclosed. An apparatus can include a synthesizer chip having an array of reaction units in a predetermined pattern, each reaction unit including a reaction surface and a reaction electrode of an IC array of reaction electrodes, and a synthesizer chip controller coupled to the IC array of reaction electrodes configured to address each reaction electrode individually. The apparatus can also include a reagent delivery chip positionable above the synthesizer chip, comprising an array of reagent delivery units arranged in the predetermined pattern, each reagent delivery unit including a reagent electrode of an IC array of reagent electrodes and each reagent delivery unit configured to receive and deliver a droplet of reagent fluid having a volume of 1 picoliter or less, and a reagent delivery chip controller coupled to the IC array of reagent electrodes configured to address each reagent electrode individually.

Massively parallel integrated circuit-based DNA synthesis devices, systems, and methods

Apparatus and methods are disclosed for electrically active combinatorial-chemical (EACC) chips for biochemical analyte detection. An apparatus includes a substrate that has an array of regions defining multiple cells, wherein each of the cells includes a reaction cavity that contains multiple functional binding groups. A method of detecting an analyte providing the reaction cavity between a source and a drain or a pair of electrodes, applying a voltage and monitoring a parameter indicative of an analyte characteristic. A process of fabricating an EACC include bonding an analyte to the multiple functional binding groups of each reaction cavity, and forming an analyte sensing structure including the substrate.

Electrically active combinatorial chemical (EACC) chip for biochemical analyte detection

Devices and methods for detecting, identifying, and sequencing, compounds, complexes, and molecules are described. Electronic detection is combined with optical excitation to determine the presence or identity of an analyte of interest. Embodiments of the invention additionally provide devices and methods that allow highly parallel nucleic acid sequence determination.

Integrated photonic electronic sensor arrays for nucleic acid sequencing

Methods, systems, and devices for detecting an analyte are disclosed and described. In one embodiment, a Metal Oxide Semiconductor (MOS) sensor pixel with a MOS active material is exposed to the analyte in the gas environment. The MOS sensor pixel is heated to a sequence of different predetermined temperatures via a heating element wherein the heating occurs for a period of time for each of the different predetermined temperatures. Response signals are detected, via an electrode, generated by the MOS sensor at each of the different predetermined temperatures. The response signals are assembled into sample data with data features for machine learning. The sample data is compared with data in a standards database. A composition of the analyte is identified based on the data features.

Metal oxide gas sensor array devices, systems, and associated methods

Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.

Device and method for detecting redox reactions in solution

Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.

Highly selective coated-electrode nanogap transducers for the detection of redox molecules

Growing community of inventors

Cupertino, CA, United States of America

Xing Su