Parker Hughes Institute

Hughes Institute

Xing-Ping Liu

Fatih M Uckun

Rama Krishna Narla

Faith M Uckun

Elise A Sudbeck

Ravi Malaviya

Vuong N Trieu

Marina Cetkovic

Vuoung N Trieu

The present disclosure includes compounds, for example a compound according to formula Ior a pharmaceutically acceptable salt thereof. The compounds of the present disclosure are useful in methods of treating cancerous conditions.

Haloanilino quinazolines and therapeutic use thereof

Quinazoline compounds and methods for the treatment of cancer and for the treatment of allergic reactions.

6,7-dimethoxyquinazolines and therapeutic use thereof

A method for preventing and treating ALS by administering a phytoestrogen, preferably genistein.

Estrogens for treating ALS

Novel substituted quinozaline compounds and conjugates useful to inhibit the growth of brain tumor cells and to inhibit adhesion and migration of brain tumor cells. The compounds of the invention include 4-(3&prime;-bromo-4&prime;-hydroxy phenyl)-amino-6,7-dimethoxyquinazoline and this compound covalently bound to EGF.

Quinazolines for treating brain tumor

The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.

Dimethoxy quinazolines for treating diabetes

Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells.

Organic arsenic compounds

Organic-arsenic compounds

Therapeutic compounds

A novel carbonyl-substituted quinazoline, preferably 4-(3&prime;-bromobenzoyl)-6,7-dimethoxyquinazoline (WHI-P164), and methods for lowering blood cholesterol, including reducing total cholesterol and LDL-cholesterol levels by administration of the carbonyl quinazolines and compositions thereof.

Lipid lowering quinazoline dietary supplement composition

6,7-Dimethoxyquinazolines and therapeutic use thereof

Lipid-lowering quinazoline derivative

6,7-Dimethoxy-4-anilinoquinaozolines of the formula:

6,7-Dimethoxy-4-anilinoquinazolines

Novel pharmaceutical compositions including melamine derivatives and methods for the treatment of cancer including prostate, brain, breast, and leukemia are described. The methods are directed to administering a therapeutically effective amount of a pharmaceutical composition including melamine derivatives having potent cytotoxic activity.

Growing community of inventors

Minneapolis, MN, United States of America

Xing-Ping Liu