Viron Therapeutics, Inc.

Jsr Corporation

The University of Western Ontario

Xing Li

Satoshi Nakamura

Grant McFadden

Alexandra Lucas

Kouji Tamori

Tetsuo Fukuta

Tomonori Shiotani

Yusuke Okano

Shun-Cheng Li

Yu Otani

Courtney Voss

The present invention relates to immunoglobulin (Ig)-binding proteins with alkali-resistance properties. In one embodiment, the present invention provides for a variant of an Ig-binding protein, the variant comprising the Ig-binding protein having at least one asparagine residue substituted with a histidine, a serine, an aspartic acid or a threonine residue. The at least one substitution may confer to the variant Ig-binding protein an increased stability in alkaline solutions when compared to the wild-type Ig-binding. The present invention relates also to matrices for affinity separation of immunoglobulins comprising the Ig-binding proteins of the present invention, and to methods of using the Ig-binding proteins of the present invention to separate immunoglobulins from mixture compositions.

Alkali-resistant variants of protein A and their use in affinity chromatography

Provided are a support for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. A support for affinity chromatography, containing an immobilized protein ligand represented by the following formula (1):R&#x2014;R&#x2003;&#x2003;(1)

Support for affinity chromatography and method for isolating immunoglobulin

The invention generally features the use of Yaba monkey tumor virus nucleic acid molecules and polypeptides for the treatment or prevention of immunoinflammatory disorders.

Immunomodulatory protein and useful embodiments thereof

The invention generally features the use of Yaba monkey tumor virus nucleic acid molecules and polypeptides for the treatment or prevention of immune-related diseases.

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London, Canada

Xing Li