Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Shanghai Huilun Life Science &technology Co., Ltd

Exxonmobil Chemical Patents Inc.

Chinese Academy of Sciences

Shanghai Huilin Life Scinece & Technology Co., Ltd.

Shanghai Targetdrug Co., Ltd.

Xing Fan

Jihong Qin

Feng He

Weikang Tao

Fanglong Yang

Jingjing Yan

Li Chen

Liang Li

Toshiaki Yamaguchi

Wenhua Li

Xiao Wu

Renhai Chen

Xiqian Zhang

Yaqiu Long

Dongzhi Feng

The present disclosure relates to a tricyclic tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, the present disclosure relates to a tricyclic tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutical composition comprising said derivative, a use thereof as an estrogen receptor modulator, and a use thereof in preparing a drug for treating estrogen receptor-mediated or dependent diseases or disorders. The substituents in general formula (I) are the same as those defined in the description.

Tricyclic tetrahydroisoquinoline derivative, preparation method therefor and application thereof in medicine

An indazole derivative, a preparation method therefor, and a pharmaceutical application thereof. In particular, the present invention relates to an indazole derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and a use of the derivative as an estrogen receptor modulator in the prevention and/or treatment of an estrogen receptor mediated or dependent disease or condition, the disease being particularly preferably breast cancer. The definition of each substituent in the general formula (I) is the same as that in the description.

Indazole derivative, preparation method therefor, and pharmaceutical application thereof

The present invention relates to the field of pharmaceutical synthesis, and in particular to an antitumor heterocyclic imidazole compound (I), namely: a pharmaceutical salt of 4-(3-(4-(1H-imidazo[4,5-b]pyridine-5-yl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(dihydro)-ketone, a preparation method therefor, a pharmaceutical composition thereof and a use thereof in the preparation of antitumor drugs. The pharmaceutical salt of the compound (I) in the present invention may be used in the preparation of a medicament for the treatment or prevention of conditions which can be improved by inhibiting PARP activity.

Pharmaceutical salt of antitumor heterocyclic imidazole compound

The present invention relates to a class of benzimidazole-2-piperazine heterocyclic derivatives, a preparation method and medical use thereof. Specifically, the present invention relates to a new benzimidazole-2-piperazine heterocyclic derivative of general Formula (I), a preparation method, a pharmaceutical composition containing the same, and use thereof as a therapeutic agent and especially as a poly(ADP-ribose)polymerase (PARP) inhibitor. 

Benzimidazole-2-piperazine heterocyclic compound, pharmaceutical composition containing the same, preparation method and use thereof

The present invention relates to heterocyclic-imidazole derivatives, a preparation method therefor, and a medical use thereof, and particularly to new heterocyclic-imidazole derivatives as represented by general formula (I), a preparation method therefor, pharmaceutical compositions comprising same, and a use thereof as a therapeutic agent, particularly as a poly(ADP-ribose)polymerase (PARP) inhibitor.

Heterocyclic-imidazole compounds, pharmaceutical compositions thereof, preparation method therefor and use thereof

The present disclosure is related to a die suitable for extrusion of thermoplastic vulcanizate, in particular for co-extrusion of multiple materials comprising a thermoplastic vulcanizate. The die comprises a pool die plate, an orifice die plate, and a profile die plate. By utilizing the die according to the present disclosure in extrusion, the flow of extrudate can be well controlled and balanced due to the design of flow pool and through orifice, thereby an extruded article achieves good shape performance, for example, good surface smoothness, and an undesired effect like edge tear, warpage, die moustache, silver line in the extrusion can be avoided.

Die and process for extrusion

The present invention pertains to the field of pharmaceutical chemistry and discloses 8-(3-aminopropyl)-3-exo-8-azabicyclo[3.2.1]octane-3-amino amide compounds represented by formula I, the pharmaceutical compositions, the preparation method and the use thereof. Such compounds or pharmaceutically acceptable salts thereof can be used as an antagonist of CCR5 in preparing medicaments for treating diseases mediated by CCR5, particularly HIV infection, asthma, rheumatoid arthritis, autoimmune diseases and chronic obstructive pulmonary diseases (COPD). 

Amide compounds, their pharmaceutical compositions, their preparation method and their uses

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Shanghai, China

Xing Fan