Merck Sharp + Dohme Corp.

Inventisbio Co., Ltd.

Inventisbio LLC

Msd Italia S.r.l.

Xing Dai

Hong Liu

Anandan Palani

Peng Li

Michael W Miller

Shuwen He

Duane E DeMong

Yueheng Jiang

Xuanjia Peng

Andrew William Stamford

Ravi P Nargund

Yaolin Wang

Nicolas Zorn

Jack D Scott

Dong Xiao

Casey Cameron McComas

Richard Soll

Jared N Cumming

Qun Dang

Kallol Basu

Zhong Lai

Yanqin Liu

Nigel J Liverton

Hao Wu

Thomas J Greshock

Frank Narjes

Uwe Koch

Joerg Habermann

Zixing Han

Zhenwu Wang

Liangshan Tao

Zhe Shi

Haotao Niu

Jifang Weng

John A McCauley

Wen-Lian Wu

Marc Poirier

Linda Brockunier

Clare London

Brandon Mitsuo Taoka

Karen M Marcantonio

William J Greenlee

Joseph A Kozlowski

John M Sanders

Bernard R Neustadt

Samuel Chackalamannil

Tao Guo

Wensheng Yu

Scott D Edmondson

Yan Xia

Ping Liu

Craig D Boyle

Brian J Lavey

Shawn P Walsh

Harold B Wood

Santhosh Francis Neelamkavil

Michael K C Wong

Wanying Sun

Guowei Zhou

De-Yi Yang

Paul Tempest

Unmesh G Shah

Joel M Harris

Ronald K Chang

Zhiyong Hu

Joie Garfunkle

Christopher R Moyes

Heather E Stevenson

Wei Li

Jonathan Kern

Jonathan T Kern

Duane Demong

Claire M Lankin

Brandon M Taoka

Byron Gabriel Dubois

Sarah W Li

Michael KC Wong

Michael Miller

Qung Dang

Nicholas Zorn

Casey Cameron Mccomas

Linda L Brockunier

Casey C Mccomas

Sarah Wei Li

John A Mccauley

Duane Eugene Demong

Charles Lee Jayne

Provided herein are novel compounds, for example, compounds having a Formula (I), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting TYK2, and/or function of IL-12, IL-23 and/or INF-alpha, and/or in treating various associated diseases or disorders.

Heteroaryl compounds, preparation methods and uses thereof

The present disclosure provides compounds of Formula (I) and Formula (II). The compounds described herein may be useful in treating proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

Selective estrogen receptor degraders and uses thereof

Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.

Heterocyclic compounds, preparation methods therefor, and methods of uses thereof

Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).

Heterocyclic compounds, preparation methods and uses thereof

The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating a disease associated with IDO, for example, cancer or an infectious disease (e.g., viral or bacterial infectious diseases). Also, provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

Inhibitor of indoleamine-2,3-dioxygenase (IDO)

Provided herein are compounds, salts, crystalline forms, and pharmaceutical compositions that are related to Selective Estrogen Receptor Degraders, as well as methods of preparing the same. Also provided herein are methods of using the compounds, salts, crystalline forms, and pharmaceutical compositions for the treatment of diseases or disorders, such as breast cancer.

Salts of selective estrogen receptor degraders

Provided herein are compounds, crystalline forms, and pharmaceutical compositions of Compound 1 and/or Compound 2. Also provided are methods of treating a disease or disorder such as a cancer or infectious disease that comprises administering to a subject in need thereof one or more of the compounds or compositions of the present disclosure.

Provided herein are compounds, salts, crystalline forms, and pharmaceutical compositions that are related to thiobutyrate compounds, such as Compound (1) and its salts (such as sodium, potassium, and calcium salt), as well as methods of preparing the same. Also provided herein are methods of using the compounds, salts, crystalline forms, and pharmaceutical compositions for the treatment of diseases or disorders, such as gout and hyperuricemia.

Salt forms of URAT-1 inhibitors

Provided herein are compounds, salts, solid forms, and pharmaceutical compositions that are related to EGFR inhibitors, such as N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide, as well as methods of preparing the same. Also provided herein are methods of using the compounds, salts, solid forms, and pharmaceutical compositions for the treatment of diseases or disorders, such as cancer.

EGFR inhibitors

Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer). 

Heterocyclic compounds, preparation and methods and uses thereof

The present disclosure provides compounds of Formula (I) and Formula (II). The compounds described herein may be useful in treating proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. 

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Cranford, NJ, United States of America

Xing Dai