Xiamen University

Yang Sheng Tang Company Limited

Xinchu Xiang

Ningshao Xia

Wenxin Luo

Quan Yuan

Tianying Zhang

Yangtao Wu

Jixian Tang

Can Wen

Disclosed are antibodies to anti-hepatitis B surface antigen (HBsAg) (especially humanized antibodies), nucleic acid molecules encoding same, methods for preparing same, and pharmaceutical compositions containing same. The antibodies have higher affinity for HBsAg at neutral pH than at acidic pH, thereby significantly enhancing the virus clearance efficiency and prolonging the virus inhibition time. The antibodies and the pharmaceutical compositions can be used for preventing and/or treating HBV infections or diseases related to HBV infections (e.g., hepatitis B), for neutralizing the virulence of HBV in a subject (e.g., a human), for reducing the serum level of HBV DNA and/or HBsAg in the body of the subject, or for activating the humoral immune response of the subject (e.g., a chronic HBV infected or chronic hepatitis B patient) against HBV.

Anti-hepatitis B virus antibody and uses thereof

Growing community of inventors

Xiamen, China

Xinchu Xiang