Bristol-Myers Squibb Compnay

Other

Xina Nair

Kenneth M Tramposch

Anne Marinier

Fred Christopher Zusi

Anna M Ericsson

Alain Martel

John E Starrett, Jr

Peter R Reczek

Retinoid antagonists and uses thereof

Certain novel substituted (5,6)-dihydroanthracenyl compounds of the general formula ##STR1## wherein A, n, p, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as defined in the specification exhibit retinoid-like properties and are particularly useful in the prevention of post-surgical adhesions.

Retinoid-like compounds

There is disclosed a synergistic composition and process for skin depigmentation with reduced irritation which does not employ a corticosteroid and which employs a substituted oxybenzene and a retinoid.

Synergistic skin depigmentation composition

There is disclosed a synergistic composition for skin depigmentation with reduced irritation which does not contain a corticosteroid comprising 4-hydroxyanisole and a retinoid, such as all-trans retinoic acid, 11-cis,13-cis-12-hydroxymethyl retinoic acid .delta.-lactone or (N-acetyl-4-aminophenyl) retinoate, in a pharmaceutically acceptable topical vehicle.

Growing community of inventors

E. Amherst, NY, United States of America

Xina Nair