Sichuan Kelun-biotech Biopharmaceutical Co., Ltd.

Xin Zhou

Jingyi Wang

Lichun Wang

Jiaqiang Cai

Hongmei Song

Qiang Tian

Hong Zeng

Mingliang Zhao

Wei Zhong

Haitao Huang

Yuting Tan

Shuai Song

Guoqing Zhong

Yao Liu

Donghai Su

Yongyong Wu

Nan Yu

Hua Deng

Lei Wu

Yitao Zhang

Yongjia Hao

Long Yang

The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with &#x3ba;-opioid receptor. The polyamide compound of the invention has excellent &#x3ba;-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain. The compound of the invention has higher selectivity for a &#x3ba;-opioid receptor, lower addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects), good patient compliance, and/or lesser propensity for developing tolerance, among other excellent medicinal properties.

Polyamide compound and use thereof

Provided in the present invention are a compound of Formula (I), a pharmaceutical composition comprising the same, a method for preparing the same, and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse transcriptase inhibitor for the prevention or treatment of viral diseases or cancers.

Nucleoside phosphate compound and preparation method and use thereof

Growing community of inventors

Chengdu, China

Xin Zhou