Amazon Technologies, Inc.

Ptc Therapeutics, Inc.

F. Hoffmann-la Roche Ag

Qualcomm Incorporated

Xin Zhao

Marta Karczewicz

Jianle Chen

Vadim Seregin

Wei-Jung Chien

Xiang Li

Gary Mitchell Karp

Nikolai A Naryshkin

Marla L Weetall

Jana Narasimhan

Amal Dakka

Timothy Allen Wagner

Emmanuel Pinard

Hasane Ratni

Amir Said

Ellen Welch

Soongyu Choi

Xiaoyan Zhang

Hongyan Qi

Sean Philip Reque

Dylan Chandler Thomas

Nanjing Zhang

Matthew G Woll

Derek Steven Manwaring

Tianle Yang

Anthony A Turpoff

Luke Green

Guangming Chen

Chunshi Li

Chang-Sun Lee

Sergey Paushkin

Song Xiao Huang

Dallas Lamont Willett

Jason Douglas Denton

Mostafa Ead

Prudhvi Janga

Lakshman Potluri

Nitin Kumar Saxena

Bharath Subramanian Pichai

Anthony A Yurpoff

Oleg Leizerov

Timothy David Ebringer

Song Huang

Nikolai Naryshkin

Vijayaraghavan Thirumalai

Sungwon Lee

Maria L Weetall

Hongbin Liu

Nan Hu

Ying Chen

Techniques for building, validating, and utilizing custom database software in a shared management environment are described. A database customization service allows users to provide database installation files as part of a configuration to generate a custom database engine version. The creation of custom database engine versions may be governed by policy, and the database customization service may provide recommendations for creating custom database engine versions according to various criteria. The custom database engine version can be built, and its functionality and correctness verified. Users may launch database instances using these custom database engine versions that can be managed under a shared management scheme where both users and the database customization service can perform host-level management.

Policies and controls for building and validating database software in a shared management environment

Provided herein are compounds of Formula (I): and forms thereof, wherein w, w, w, w, w, wand ware as defined herein, including compositions thereof and uses therewith for treating spinal muscular atrophy.

Compounds for treating spinal muscular atrophy

A system for providing automatic resource resizing is provided. The system may be configured to maintain a plurality of virtual machine instances. The system may be further configured to receive a request to execute a program code and allocate computing resources for executing the program code on one of the virtual machine instances. The amount of resources allocated for executing the program code may be specified by the request and adjusted as needed.

Automatic determination of resource sizing

Provided herein are compounds of Formula (I): 

A system for providing dynamic code deployment and versioning is provided. The system may be configured to receive a first request to execute a newer program code on a virtual compute system, determine, based on the first request, that the newer program code is a newer version of an older program code loaded onto an existing container on a virtual machine instance on the virtual compute system, initiate a download of the newer program code onto a second container on the same virtual machine instance, and causing the first request to be processed with the older program code in the existing container.

Dynamic code deployment and versioning

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.

Automatic management of resource sizing

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.

Growing community of inventors

Belle Mead, NJ, United States of America

Xin Zhao