Fujifilm Cellular Dynamics, Inc.

Xin Zhang

Maksym A Vodyanyk

Deepika Rajesh

Wen Bo Wang

Sarah Burton

Christie Munn

Bradley Swanson

Andrew J Brandl

Ethan McLEOD

Provided herein are methods for the production of antigen-specific effector T cells and NK cells from pluripotent stem cells which express a chimeric antigen receptor (CAR). Further provided herein are methods for the adoptive cell therapy by administering the effector T cells and/or NK cells provided herein.

Antigen-specific immune effector cells

Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.

Methods for directed differentiation of pluripotent stem cells to immune cells

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Madison, WI, United States of America

Xin Zhang