Cornell University

Novita Pharmaceuticals, Inc.

Cornell Research Foundation Inc.

Sloan-kettering Institute for Cancer Research

Xin-Yun Huang

Christy Young Shue

Samuel J Danishefsky

Christoph Gaul

Jón T Njardarson

Jue Jillian Zhang

Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof.

Methods for inhibiting fascin

Provided are compounds, compositions and methods for inhibiting fascin activity or treating a condition or disorder mediated by fascin activity in a subject in need thereof.

Compounds and methods for inhibiting fascin

Provided are methods of increasing a response to a chemotherapeutic agent or an immunotherapeutic agent in a patient in need thereof, and methods of treating cancer in a patient in need thereof, comprising administering to the patient a chemotherapeutic agent or an immunotherapeutic agent and a metastasis inhibiting compound, as described in this disclosure.

Co-therapies including a metastasis inhibitor

The invention provides an agent that reduces the expression of G&#x3b1;or G&#x3b1;polypeptide, as well as an agent that enhances G protein G&#x3b1;or G&#x3b1;expression and/or activity. An agent of the invention may be used to decrease or increase G protein G&#x3b1;or G&#x3b1;expression and/or activity thereby to treat or prevent the onset of a disease or condition associated with G&#x3b1;or G&#x3b1;expression and/or activity. The invention also provides a method for screening for an anti-cancer or anti-angiogenesis agent, as well as an agent that promotes angiogenesis.

G proteins in tumor growth and angiogenesis

In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I),  In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Migrastatin analog compositions and uses thereof

The present invention relates to a method of designing an ion channel blocker for an ion channel which includes providing an ion channel having an external vestibule portion and raising an antibody, binding portion, probe, or ligand specific to the external vestibule portion of the ion channel, where the antibody, binding portion, probe, or ligand inhibits ion transport through the ion channel. The present invention further relates to a method of inhibiting ion transport through an ion channel, a method for screening a drug for effectiveness as an ion channel blocker, and an antibody, binding portion, probe, or ligand.

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New York, NY, United States of America

Xin-Yun Huang