Genentech, Inc.

Consolidated Metco Incorporated

Amgen Inc.

Xin Yu

Dan L Eaton

Jane Louise Grogan

Jason A Hackney

Kristin Bowles

Bryan Irving

Robert J Johnston

Laetitia Comps-Agrar

Hilary Clark

Lino Gonzalez, Jr

Mark Robert Brasch

Shunsuke Takenaka

Fernando Garces

Deepali Sawant

Jackson Egen

AeRyon Kim

Jane L Grogan

Kristin D Harden

A bearing seal includes a seal case, a sleeve, and a thrust bumper that is disposed between the seal case and the sleeve and that is composed of a material that is at least 90% polytetrafluoroethylene by weight. The thrust bumper has an initial axial thickness that defines a spacing between the seal case and the sleeve when the seal case and the sleeve are compressed together during assembly of the bearing seal. The thrust bumper has a modified axial thickness less than the initial axial thickness after a break-in phase of the bearing seal.

Bearing seal with polytetrafluoroethylene thrust bumper

The present invention relates to a human agonistic CD40 multispecific antibody construct for treatment of solid tumors by engineering a molecule that specifically targets the CD40 pathway on tumor-associated APCs, without systemic CD40 activation.

Mesothelin-targeted CD40 agonistic multispecific antibody constructs for the treatment of solid tumors

A bearing seal includes a seal case, a sleeve, and a thrust bumper disposed between the seal case and the sleeve to define spacing between the seal case and the sleeve during assembly of a wheel end implementing the bearing seal. The thrust bumper includes polytetrafluoroethylene.

The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Compositions and methods for the treatment of immune related diseases

A seal case for a bearing seal includes (a) an inner case encircling a rotation axis of the bearing seal, (b) an outer case encircling the rotation axis and including a ring-shaped frame and a rubber gasket over-molded on the frame, and (c) a plastic wafer clamped between the inner case and the outer case, and secured at least by the rubber gasket. A method for manufacturing a bearing seal includes over-molding a rubber gasket onto a ring-shaped frame to form an outer case, placing a plastic wafer between the rubber gasket and an inner case, and securing the inner case to the outer case to form a seal case.

Seal case with over-molded rubber gasket securing plastic wafer

The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.

Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors

Methods of treating cancer using PD-1 axis binding antagonists and tigit inhibitors

A heavy duty vehicle hubcap assembly is provided. The hubcap assembly includes a main section with flanges and flange holes for mounting to a wheel hub. The main section of the hubcap assembly also includes an opening to receive a plug assembly. The plug assembly is comprised of a main section, usually comprised of rubber, and a baffle section, usually comprised of a plastic material. The main section includes a restrictive opening to allow equalization of air pressure between the inside seal portion of the hub cap assembly and the atmosphere.

Vehicle wheel hubcap with vent

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Foster City, CA, United States of America

Xin Yu