Arbutus Biopharma Corporation

Xin Ye

James Heyes

Adam Judge

Mark Wood

Amy C H Lee

Richard James Holland

Alan Martin

Nicholas Michael Snead

Emily P Thi

The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

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Richmond, CA, United States of America

Xin Ye