Merck Sharp + Dohme Corp.

Xin Yan

Ping Liu

Gregori J Morriello

Derun Li

Santhosh Francis Neelamkavil

Peter H Fuller

John J Acton, Iii

Vladimir Simov

Kaitlyn Marie Logan

Luis Torres

William P Kaplan

Michael J Ardolino

Barbara A Pio

Joey Lee Methot

Phieng Siliphaivanh

Solomon D Kattar

Jing Su

Nunzio Sciammetta

Yi-Heng Chen

Hakan Gunaydin

Qinglin Pu

Min Lu

Brett A Hopkins

Wenlang Fu

Sulagna Sanyal

Anmol Gulati

Meredeth A Mcgowan

Joanna L Chen

George Madalin Giambasu

Rebecca Elizabeth Johnson

Mitchell H Keylor

John J Iii Acton

Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.

IL4I1 inhibitors and methods of use

The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

1-pyrazolyl, 5-, 6-disubstituted indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof

The present invention is directed to substituted certain N-heteroaryl indazole derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R, R, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

N-heteroaryl indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof

Growing community of inventors

Newton, MA, United States of America

Xin Yan