City University of Hong Kong

Xin Wang

Peng Shi

Wenjun Zhang

Xudong Lin

Linfeng Huang

Yuet Ming Rebecca Chin

Jianyang Hu

Zixun Wang

A method of determining one or more target nucleic acids in cells includes the steps of: delivering one or more probes into the cells, each of the one or more probes being capable of binding with corresponding target nucleic acid present in the cells to form a double-stranded sequence; inserting an array of functionalized nanoneedles into the cells to bind with the double-stranded sequence; and hybridizing the bound double-stranded sequence with a first and second DNA sequence to produce a hybridized product, the first and second DNA sequence being at least partially complementary to each other. A kit for determining a target nucleic acid in cells includes a first reagent comprising a probe for binding with the target nucleic acid to form a double-stranded sequence; and an array of functionalized nanoneedles comprising a protein for binding with the double-stranded sequence.

Method of determining target nucleic acid

A method for analyzing neuropharmacology of a drug, including the steps of providing a set of brain activity maps representing changes of a brain activity of a living species under an influence of a plurality of known drugs each consisting of a known chemical structure; clustering the set of brain activity maps to form a plurality of functional classifiers; and classifying a brain activity map associated with a chemical compound using the functional classifiers so as to predict a neuropharmacology of the chemical compound.

Method and a system for analyzing neuropharmacology of a drug

A gRNA molecule includes a first domain complementary to at least a portion of TCOF1 gene, and a second domain for binding with Cas9 protein, and a kit includes the gRNA molecule. A method of treating a subject suffering from a cancer associated with an elevated expression of TCOF1 gene includes the step of administering an effective amount of a first recombinant vector comprising the gRNA molecule of the invention to the subject. A method of inhibiting the expression of TCOF1 gene in cancer cells associated with an elevated expression of TCOF1 gene includes contacting the cancer cells with a first recombinant vector, wherein the first recombinant vector comprises a gRNA molecule comprising a first domain complementary to at least a portion of TCOF1 gene and a second domain binding with Cas9 protein.

Guide RNA molecule and method for treating cancer

Growing community of inventors

Hong Kong, China

Xin Wang